| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| John Goodman | Glenallen Walken |
| James Cromwell | President D. Wire Newman |
| Michael Hyatt | Angela Blake |
| Stephen Tobolowsky | Dr. Max Milkman |
| Terry O'Quinn | General Nicholas Alexander |
| Allison Smith | Mallory O'Brien |
| Ron Canada | Under Secretary of State Theodore Barrow |
| Diana Douglas | Libby Lassiter |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| Maz Jobrani | Prince Bitar |
| Bellamy Young | MaryLou Meriwether |
| Ryan Cutrona | CIA Director George Rollie |
| David Andriole | Ralph Fairfax |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Kris Murphy | Katie Witt |
| Devon Michaels | Randal Fierstin |
| Don Fischer | Lieutenant Colonel Castorp |
| Austin Priester | Secret Service Agent |
| Mitch Gibney | Talking Head |
| Jerry Buys | Secret Service Agent
(uncredited) |
| Ammar Daraiseh | Saudi Newscaster
(uncredited) |
| Christine Holz-Lusita | HR Assistant
(uncredited) |
| Aaron Michael Lacey | Secret Service Agent
(uncredited) |
| Eiko Nijo | Japanese Newscaster
(uncredited) |
| Jennifer Rouse | Secret Service Agent
(uncredited) |
| Laura Ann Tull | Press
(uncredited) |