| Stockard Channing | Abbey Bartlet |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Mary-Louise Parker | Amy Gardner |
| Jesse Bradford | Ryan Pierce |
| William Devane | Secretary of State Lewis Berryhill |
| John Amos | Percy Fitzwallace |
| Lily Tomlin | Deborah Fiderer |
| Elisabeth Moss | Zoey Bartlet |
| Nina Siemaszko | Ellie Bartlet |
| Annabeth Gish | Elizabeth Bartlet Westin |
| Kathleen York | Andrea Wyatt |
| Clark Gregg | FBI Special Agent Michael Casper |
| Michael Hyatt | Angela Blake |
| Zeljko Ivanek | Steve Atwood |
| Steven Eckholdt | Doug Westin |
| NiCole Robinson | Margaret Hooper |
| Renée Estevez | Nancy |
| Saïd Taghmaoui | Qumari Ambassador Umar Usef |
| Dan Manning | Agent Elliott |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Devika Parikh | Bonnie |
| Rick Cramer | Colonel |
| Shireen Kadivar | Anne Shahrair |
| Esther K. Chae | McKenzie |
| Timothy Davis-Reed | Mark O'Donnell |
| Brian Dragonuk | FBI Agent
(uncredited) |
| John Goodman | Glenallen Walken
(uncredited) |
| Ralph Kampshoff | Rear Admiral Payne
(uncredited) |
| Aaron Michael Lacey | Marine
(uncredited) |
| Paul Majors | Secret Service Agent
(uncredited) |
| Anna Deavere Smith | Nancy McNally
(uncredited) |