| Jessica Biel | Cora Tannetti |
| Christopher Abbott | Mason Tannetti |
| Dohn Norwood | Dan Leroy |
| Abby Miller | Caitlin Sullivan |
| Bill Pullman | Harry Ambrose |
| Jacob Pitts | J.D. |
| Joanna Adler | Captain Anne Farmer
(as Joanna P. Adler) |
| Enid Graham | Cora's Mom |
| Nadia Alexander | Adult Phoebe (19) |
| Patti D'Arbanville | Lorna Tannetti |
| Robert Funaro | Ron Tannetti |
| Eric Todd | Frankie Belmont |
| Orlagh Cassidy | Elsa Belmont |
| Christopher Innvar | Frankie's Dad |
| Susan Pourfar | Cora's Public Defender |
| Joseph Melendez | District Attorney Lopez |
| Peggy Gormley | Judge Barrett |
| Danielle Burgess | Maddie |
| Robert Cuccioli | Bruce Herting |
| Lindsay Torrey | Abbi Grayston |
| Grant Monohon | Duffy |
| Gene Presendieu Jr. | Craig |
| Grayson Eddey | Laine Tannetti |
| John Rue | Henry |
| Aamira Martinez | Corrections Officer |
| Jacob Berger | Bailiff |
| Cristina Pitter | Prison Guard
(as Christina Pitter) |
| Amanda Anthony | Courthouse Spectator
(uncredited) |
| Assibey Blake | Guard /
Husband
(uncredited) |
| Michele Cannon | Inmate
(uncredited) |
| Merritt Chase | Press Conference Attendee
(uncredited) |
| Takako Haywood | Clerical Worker
(uncredited) |
| Frank Holley | Sheriff's Deputy
(uncredited) |
| Annie Pisapia | Pedestrian
(uncredited) |
| Sherri Robinson | News Crew Sound Person
(uncredited) |