| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Paula Garcés | Tina Hanlon
(as Paula Garces) |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Jay Karnes | Holland Wagenbach |
| David Marciano | Steve Billings |
| Benito Martinez | David Aceveda |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| CCH Pounder | Claudette Wyms |
| Laurie Holden | Agent Olivia Murray |
| Michele Hicks | Mara Sewell Vendrell |
| Kyle Gallner | Lloyd Denton |
| Francesco Quinn | Beltran |
| Peter Macon | Vernon |
| Stu 'Large' Riley | Stu |
| Paul Dillon | Chaffee |
| Autumn Chiklis | Cassidy Mackey |
| Magi Avila | Santi's Girlfriend |
| Cindy Chiu | Grocery Clerk |
| Cherie Gierhart | Kim
(as Cherie Dvorak) |
| Miles Greenberg | Jackson Vendrell |
| Ben Hernandez Bray | Santi
(as Benny Hernandez) |
| Danny Pardo | Cartel Driver |
| Aaron Skinner | ICE Agent |
| Jack Weber | Matthew Mackey |
| André 3000 | Robert Huggins
(as André Benjamin) |
| Mark Atteberry | Marshal Reynolds |
| Joanne Baron | Marianne |
| Julia Campbell | Ellen Carmichael |
| Clark Johnson | Handsome Marshall |
| Jaquiya Jones | Freeman's Daughter |
| M. Martin Mapoma | Detainee |
| Remy Ryan | Mona |
| Sandra Sanchez | News Reporter |
| Kristina Sexton | Pitcha |
| Tamika Simpkins | Freeman's Wife |
| Kozue Tatgoa | Lloyd's Lawyer |
| Roy Vongtama | EMT |
| Ruben Avitia | Background Detective
(uncredited) |
| Lewis Black | Lawyer
(voice) (uncredited) |
| Diane Modafferi | Cop
(uncredited) |
| Lee von Ernst | Cop
(uncredited) |