| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| CCH Pounder | Claudette Wyms |
| Alex O'Loughlin | Kevin Hiatt |
| David Marciano | Steve Billings |
| Paula Garcés | Tina Hanlon
(as Paula Garces) |
| F.J. Rio | Cruz Pezuela |
| Christopher Cousins | Benjamin Webb |
| Kwame Patterson | Streetz |
| Hector Luis Bustamante | Luis Aramboles |
| Franka Potente | Diro Kesakhian |
| Autumn Chiklis | Cassidy Mackey |
| Patrick O'Connor | Romero's Lawyer |
| Ludwig Manukian | Ellis Rezian |
| Ada Luz Pla | Desda |
| Casey Washington | Jimmy Barnes |
| Chaney Kley | Officer Asher |
| John R. McLaughlin | Ray
(as John McLaughlin) |
| Liz Montgomery | Mary |
| Baxter Humby | Romero |
| J. David Shanks | Officer Stamos |
| Jack Weber | Matthew Mackey |
| Mike Foy | Bones
(as Mike 'Skripture' Foy) |
| Raff Anoushian | Zadofian |
| Kareem J. Grimes | Burnout
(as Kareem Grimes) |
| Dabier | Rebound
(as Dabier Snell) |
| Melanie Myers | Paula |
| Omari Hughes | Older Kid |
| Angela Sargeant | Clerk |
| Cathleen Oveson | Gina
(as Cathleen Johnson) |
| Brian Thomas Abraham | Sarkis
(as Brian Abraham) |
| Ruben Avitia | Background Detective
(uncredited) |
| Dolores Quintana | Woman (on blackmail picture)
(uncredited) |