| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| CCH Pounder | Claudette Wyms |
| Forest Whitaker | Jon Kavanaugh |
| David Marciano | Steve Billings |
| Paula Garcés | Tina Hanlon
(as Paula Garces) |
| Onahoua Rodriguez | Emolia Melendez |
| Lela Loren | Nydia Hernandez |
| Al Israel | Jupo Nunez |
| Jordi Caballero | Aldo Melchor |
| Miguel Nájera | Mexican D.F. Officer
(as Miguel Najera) |
| Chaney Kley | Officer Asher |
| Ben Hernandez Bray | Santi
(as Benny Hernandez) |
| Lorenzo Eduardo | Big G |
| Saul Huezo | Maceo |
| Edward Meza | Petro |
| Alexis Hernandez | Tito |
| Julian Scott Urena | Rocha |
| Jerry Hernandez | Young Salvadoran |
| Michele Moreno | Consuela |
| Brad Jacobowitz | Police Officer
(uncredited) |