| Michael Chiklis | Vic Mackey |
| Glenn Close | Monica Rawling |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| Rebecca Pidgeon | Joanna Faulks |
| Camillia Monet | Aurora Aceveda
(as Camillia Sanes) |
| David Marciano | Steve Billings |
| RonReaco Lee | Taylor Orrs |
| Kurt Caceres | Juan Lozano |
| Nigel Gibbs | Assistant Chief Roy Phillips |
| Darrow Igus | Mr. Porter |
| Cliff Weissman | Perry |
| Cathy Lind Hayes | Heidi Prue |
| Faleolo Alailima | Francis /
'Bumper' |
| Anthony Anderson | Antwon Mitchell |
| Linda Friedman | Nina |
| Sofie Calderon | Elisa |
| Katia Bokor | Irina |
| Michael Khmurov | Tretiak
(as Michael Khmourov) |
| Roman Varshavsky | Osip |
| La Monde Byrd | Jason Porter |
| Ron Bottitta | C4 Engineer |
| April Gooding | Officer Teresa |
| Isabel Mares | Sophia |
| Ruben Avitia | Background Detective
(uncredited) |