| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| Nicki Micheaux | Trish George |
| Gareth Williams | Walon Burke |
| Camillia Monet | Aurora Aceveda
(as Camillia Sanes) |
| Vincent Angell | Lyor Slavaik |
| Rashaan Nall | Tobar |
| Noel Gugliemi | Prophets gang leader |
| Dwayne Barnes | Link
(as Dwayne L. Barnes) |
| Paul Benjamin | Perry |
| Andrew Borba | Crosby Nell |
| William Stanford Davis | Deon |
| Neko Parham | Twizzy
(as M. Neko Parham) |
| Michele Hicks | Mara Sewell |
| Gary Cruz | Neron |
| Linda Friedman | Nina |
| Aisha Hinds | Annie Price |
| Nigel Gibbs | Assistant Chief Roy Phillips |
| Kenneth Colom | Officer Lucas |
| Autumn Chiklis | Cassidy Mackey |
| Joel Rosenthal | Matthew Mackey |
| Veronica Del Palacio | Gitana |
| La Trice Harper | Oleana |
| Lorne Hughes | Merril Jindrich
(as Lonnie Hughes) |
| Oren Williams | Kid |
| Roger Marks | Yosef Rabinowitz |
| Yoann Cifuentes | Avram Rabinowitz |
| Tom Holiday | Reverend |
| Tom Yi | Detective Rodriguez |
| Steve Cell | Cobalt |
| Samuel Le | Tung Yung |
| Kurt Caceres | Juan Lozano
(uncredited) |
| Wilmer Calderon | Ricky
(uncredited) |