| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| Ron Canada | Chief of Police Tom Bankston |
| Brian White | Tavon Garris |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| Monnae Michaell | Vanessa |
| Camillia Monet | Aurora Aceveda
(as Camillia Sanes) |
| Frank Grillo | Officer Paul Jackson |
| Tracie Thoms | Bonnie |
| Matt Corboy | Ray Carlson |
| T.J. Hall | Randall |
| Dominic Comperatore | Dach |
| Herzl Tobey | Chorekian |
| Gilbert Glenn Brown | Lops |
| Darris Love | Boxer |
| Jonathan Roger Neal | Mouser |
| Mario Larraza | Herman |
| Ric Sarabia | Radiohead |
| Rick Garcia | Newscaster |
| Lancer Dean Shull | Nice Guy |
| Brett Stimely | Reporter #1 |
| Michele Gregory | Reporter #2 |
| Erick Carrillo | Quazi
(uncredited) |
| Terrence Flack | Tike
(uncredited) |
| Nick Hermz | Armenian Mobster
(uncredited) |
| James Martin Kelly | Internal Affairs Detective
(uncredited) |
| Barry Sigismondi | Sheriff
(uncredited) |