| Michael Chiklis | Vic Mackey |
| Catherine Dent | Danni Sofer |
| Walton Goggins | Shane Vendrell |
| Michael Jace | Julien Lowe |
| Kenny Johnson | Curtis Lemansky |
| Jay Karnes | Holland Wagenbach |
| Benito Martinez | David Aceveda |
| CCH Pounder | Claudette Wyms |
| John Diehl | Assistant Chief Ben Gilroy |
| Lana Parrilla | Sedona Tellez |
| Cedric Pendleton | Tio |
| Cathy Cahlin Ryan | Corrine Mackey |
| David Rees Snell | Ronnie Gardocki |
| Matt Corboy | Ray Carlson |
| Arlen Escarpeta | Sonny |
| Rick Allen | Riot Squad Cmdr |
| Malieek Straughter | Cyrus |
| P.B. Smiley | Witness
(as PB Smiley) |
| Aurelia Sweeney | Betty |
| Alex Veadov | Igal |
| Pamala Tyson | Escrow Clerk |
| Galen Yuen | Transient |
| Damen Fletcher | Benji |
| William Badgett | Junkie Dad
(as Will Badgett) |
| Whitney Shannon | Hooker |
| Roman Arabia | Drive-by shooter |
| Melanie Myers | Paula |
| Rodney Wilson | Reporter
(as Roddy Schaef) |
| Blake Hightower | Boy#1 |
| Omar McClinton | Officer Roman
(uncredited) |
| Petra Sprecher | Twanya
(uncredited) |