| James Badge Dale | PFC Robert Leckie |
| Joseph Mazzello | Eugene Sledge |
| Jon Seda | Sgt. John Basilone |
| Jon Bernthal | Sgt. Manuel Rodriguez |
| Joshua Bitton | Sgt. J.P. Morgan |
| Tom Budge | PFC Ronnie Gibson |
| Linda Cropper | Mary Frank Sledge |
| Caroline Dhavernas | Vera Keller |
| Josh Helman | PFC Lew 'Chuckler' Juergens |
| Ashton Holmes | PFC Sidney Phillips |
| Toby Leonard Moore | Sgt. Stone |
| Henry Nixon | 2nd Lt. Hugh Corrigan |
| Keith Nobbs | PFC Wilbur 'Runner' Conley |
| Conor O'Farrell | Dr. Sledge |
| Jacob Pitts | PFC Bill 'Hoosier' Smith |
| William Sadler | Lt Col. Lewis 'Chesty' Puller |
| Simon Bossell | Corpsman Stern |
| Mark Casamento | George Basilone |
| Lelia Goldoni | Dora Basilone |
| Chris Haywood | John Leckie |
| Brynn Loosemore | Corpsman Lewis |
| Luigi Lucente | Carlo Basilone |
| Louis Toshio Okada | Panicked Japanese Soldier |
| Paul Pantano | Angelo Basilone |
| Jon Seda Jr. | Basilone Nephew |
| Joseph R. Sicari | Salvatore Basilone |
| Sandy Winton | Capt. Jameson |
| Tom Hanks | Narrator |
| Darren Bailey | Mess Hall Marine |
| Sebastian Bertoli | Marine |
| Byron J. Brochmann | US Marine - B Corps |
| Nathin Butler | Private Young |
| Michael Patrick Carmody | Soldier |
| Vince Cefalu | Sgt. Major |
| Joshua Close | Edward Sledge |
| Eddie Hardy | Marine |
| Callan Lewis | US Marine |
| David Ludlow | Pvt. Lil'One |
| Julia Mazzucato | Little sister |
| Braydn Michael | Robert Marshall |
| Chris Milligan | Marine |
| Ben L. Mitchell | Marine |
| Joe Russell | Commissary Marine |
| James Straiton | Marine |
| Mathew Waters | Weeping Marine |