| Steven Strait | Jim Holden |
| Cas Anvar | Alex Kamal |
| Dominique Tipper | Naomi Nagata |
| Wes Chatham | Amos Burton |
| Frankie Adams | Roberta 'Bobbie' W. Draper |
| Shohreh Aghdashloo | Chrisjen Avasarala |
| Thomas Jane | Joe Miller |
| David Strathairn | Commander Klaes Ashford |
| Cara Gee | Camina Drummer |
| Nadine Nicole | Melba Koh |
| Genelle Williams | Tilly Fagan |
| Raven Dauda | Namono 'Nono' Volovodov |
| Anna Hopkins | Monica Stuart |
| Zach Villa | Maneo |
| Brandon McGibbon | Cohen |
| John Kapelos | Ren |
| Ari Millen | Stanni |
| Paulino Nunes | Reverend Doctor Hector Cortez |
| Elizabeth Mitchell | Reverend Doctor Anna Volovodov |
| Adam Bogen | Maneo's Brother |
| Andrew Rotilio | Diogo |
| Bo Martynowska | Evita |
| Brock Johnson | Grigori |
| Chris Owens | Kolvoord |
| Craig Burnatowski | Buyer |
| James Lafazanos | Belter #1 (Dealer) |