| Steven Strait | Jim Holden |
| Cas Anvar | Alex Kamal |
| Dominique Tipper | Naomi Nagata |
| Wes Chatham | Amos Burton |
| Frankie Adams | Roberta 'Bobbie' W. Draper |
| Shawn Doyle | Sadavir Errinwright |
| Shohreh Aghdashloo | Chrisjen Avasarala |
| Chad L. Coleman | Col. Frederick Lucius Johnson |
| Terry Chen | Praxideke 'Prax' Meng |
| Nick E. Tarabay | Cotyar |
| François Chau | Jules-Pierre Mao |
| Byron Mann | Admiral Nguyen |
| Ted Atherton | Dr. Strickland |
| Elizabeth Mitchell | Reverend Doctor Anna Volovodov |
| Jonathan Whittaker | Sec-Gen Gillis |
| Jordan Dacol | Katoa Hybrid |
| Leah Madison Jung | Mei |
| Martin Roach | Admiral Souther |
| Michael Brown | Lt. Lipson |
| Nicole Stamp | Medical Tech |
| Nolan Greenwald | Mao Bodyguard #2 |
| Ryan Maramieri | Prospero Child |
| Sydney Ozerov-Meyer | Ensign Larson |
| Tyler Blake Smith | Mao Bodyguard #1 |
| Elias Toufexis | Monster |