| Jared Padalecki | Sam Winchester |
| Jensen Ackles | Dean Winchester |
| Misha Collins | Castiel |
| Mark Sheppard | Crowley
(as Mark A. Sheppard) |
| Emily Swallow | The Darkness |
| Laci J Mailey | Deputy Jenna Nickerson
(as Laci J. Mailey) |
| Aaron Hill | Mike Schneider |
| Lauren K. Robek | Marnie /
Crowley
(as Kirsten Robek) |
| Kurt Evans | Marnie's Husband |
| Duncan Minett | Dale |
| Jillian Fargey | Deb |
| Ryan Grantham | Hunter Boy #1 |
| Dylan Archambault | Efram |
| Albert Nicholas | Jonah |
| Lee Shorten | Minion #1 |
| Jesse Reid | Minion #2 |
| Maja Aro | Rabid Nurse
(uncredited) |
| Lane Edwards | Angel
(uncredited) |
| Dan Shea | Old Man
(uncredited) |