| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Drea de Matteo | Wendy Case |
| Tommy Flanagan | Filip 'Chibs' Telford |
| David Labrava | Happy Lowman
(credit only) |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Jimmy Smits | Nero Padilla |
| Annabeth Gish | Lieutenant Althea Jarry |
| Emilio Rivera | Marcus Alvarez |
| Michael Beach | Taddarius Orwell 'T.O.' Cross |
| Malcolm-Jamal Warner | Sticky |
| Marilyn Manson | Ron Tully |
| Brad Carter | Leland Gruen |
| Lea Michele | Gertie |
| Ivo Nandi | Oscar El Oso Ramos |
| Rusty Coones | Rane Quinn |
| Mo McRae | Tyler Yost |
| Marya Delver | Sheriff Eglee |
| Shawn Woods | Dulain |
| Mackenzie Parker | Scoot |
| Carlos E. Campos | Latino Man |
| Raleigh Barmer | East Dub Hitter
(uncredited) |
| Damien Bray | Mayan
(uncredited) |
| Jenko Childs | East Dub Hitter
(uncredited) |
| Natalie Skyy | Kiki
(uncredited) |