| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow |
| Jimmy Smits | Nero Padilla |
| CCH Pounder | Tyne Patterson |
| Drea de Matteo | Wendy Case |
| David Labrava | Happy Lowman |
| Kim Dickens | Colette Jane |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| McNally Sagal | Margaret Murphy |
| Timothy V. Murphy | Galen O'Shay |
| Kenneth Choi | Henry Lin |
| Rusty Coones | Rane Quinn |
| Douglas Bennett | Orlin West |
| Keone Young | Bohai Lin |
| Jacob Vargas | Allesandro Montez |
| Jeff Wincott | James 'Jimmy' Cacuzza |
| Evan Londo | Abel |
| Ryder Londo | Abel |
| Scott Anderson | Connor Malone |
| Steven El Ray Parker | Elias
(as Steven El Ray Parker Jr.) |
| Alfred Rubin Thompson | Tyson |
| Kevin Fry | Neil
(as Kevin Fry-Bowers) |
| Alan O'Neill | Hugh |
| Anastasia Baranova | Escort |
| David Haley | Sheriff Jenkins
(uncredited) |
| Sophia Markov | Thomas Teller
(uncredited) |
| Victoria Markov | Thomas Teller
(uncredited) |
| Marcus Natividad | Chinese Thug #1
(uncredited) |
| Cassandra Starr | Escort
(uncredited) |
| Madeleine Wade | Escort
(uncredited) |