| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Drea de Matteo | Wendy Case |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Harold Perrineau | Damon Pope |
| Donal Logue | Lee Toric |
| Jimmy Smits | Nero Padilla |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| David Labrava | Happy Lowman |
| Winter Ave Zoli | Lyla Winston |
| Emilio Rivera | Marcus Alvarez |
| Robin Weigert | Ally Lowen |
| Billy Brown | August Marks |
| Dave Navarro | Arcadio Nerona |
| McNally Sagal | Margaret Murphy |
| Chris Reed | Philip 'Filthy Phil' Russell
(as Christopher Douglas Reed) |
| Olivia Burnette | Homeless Woman |
| Reynaldo Gallegos | Fiasco
(as Rey Gallegos) |
| Scott Lawrence | A.D.A. |
| LaMonica Garrett | Deputy Cane |
| Ramon Fernandez | Dante |
| Matt Orduna | Dr. Balian
(as Matt Orduña) |
| Beth Payne | Anya |
| Ezra Masters | Dog Owner |
| Ramon Camacho | Banger |
| Diana R. Lupo | Mini Van Woman
(uncredited) |
| Anthony Martins | Triple 2 Gang Member #5
(uncredited) |
| Marco Morales | Triple Two #2
(uncredited) |
| Allen Singh | Gang Member
(uncredited) |
| Kurt Sutter | Otto
(uncredited) |