| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow |
| Danny Trejo | Romero 'Romeo' Parada |
| Benito Martinez | Luis Torres |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Harold Perrineau | Damon Pope |
| Sonny Barger | Lenny 'The Pimp' Janowitz |
| David Labrava | Happy Lowman |
| Jeff Kober | Jacob Hale, Jr. |
| Michael Beach | Taddarius Orwell 'T.O.' Cross |
| Tara Summers | Karen Dunhill |
| McNally Sagal | Margaret Murphy |
| Wally Rudolph | Chris 'V-Lin' Von Lin |
| Niko Nicotera | George 'Ratboy' Skogstrom |
| Chris Reed | Philip 'Filthy Phil' Russell |
| Karina Logue | Nurse Toric |
| LaMonica Garrett | Deputy Cane |
| Winston James Francis | Hightower |
| Natalie Skyy | Olsen Twin |
| Kurt Sutter | Otto |