| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow |
| Harold Perrineau | Damon Pope |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Jimmy Smits | Nero Padilla |
| David Labrava | Happy Lowman |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Winter Ave Zoli | Lyla Winston |
| Chuck Zito | Frankie Diamonds |
| McNally Sagal | Margaret Murphy |
| Mo McRae | Tyler Yost |
| Chris Reed | Philip 'Filthy Phil' Russell
(as Christopher Douglas Reed) |
| Antonio D. Charity | Ray Barnes |
| Jaime Zevallos | EMT |
| Karina Logue | Nurse Pamela Torric
(uncredited) |
| Angelo Romanelli | Cacuzza
(uncredited) |