| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow |
| Harold Perrineau | Damon Pope |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Jimmy Smits | Nero Padilla |
| Emilio Rivera | Marcus Alvarez |
| David Labrava | Happy Lowman |
| Billy Brown | August Marks |
| Wanda De Jesus | Carla |
| Jack Conley | Sergeant Mackey |
| Chuck Zito | Frankie Diamonds |
| Joel McHale | Warren |
| Chris Browning | Gogo |
| Merle Dandridge | Rita Roosevelt |
| Chris Reed | Philip 'Filthy Phil' Russell |
| Kenneth Choi | Henry Lin |
| Kurt Yaeger | Greg the Peg |
| Mo McRae | Tyler Yost |
| Bruce Gray | Dr. Hacker |
| Nick Jaine | Doctor |
| Stephen Mendel | Dr. Ross |
| Malcolm Foster Smith | Bucky |
| Francesca Casale | Sookie Mackey |
| Michelle Dunker | Nurse |
| Bob Rusch | Skeeter |
| Kurt Sutter | Otto 'Big Otto' Delaney |