| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser
(credit only) |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles Teller |
| Ron Perlman | Clarence 'Clay' Morrow |
| Danny Trejo | Romero 'Romeo' Parada |
| Benito Martinez | Luis Torres |
| Rockmond Dunbar | Lieutenant Eli Roosevelt |
| Jimmy Smits | Nero Padilla |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| David Labrava | Happy Lowman |
| Jeff Kober | Jacob Hale, Jr. |
| Chuck Zito | Frankie Diamonds |
| Marshall Allman | Devin Price |
| Brad Grunberg | Allen Biacone |
| Chris Browning | Gogo |
| Merle Dandridge | Rita Roosevelt |
| Timothy V. Murphy | Galen O'Shay |
| Kurt Yaeger | Greg the Peg |
| Chris Reed | Philip 'Filthy Phil' Russell
(as Christopher Douglas Reed) |
| Walton Goggins | Venus Van Dam |
| LaMonica Garrett | Deputy Sheriff Cane |
| Matt Orduna | Dr. Balian
(as Matt Orduña) |
| Sheila Shaw | ER Nurse |
| Andy Earnest Spencer | Black Banger
(as Andy Spencer) |
| Vanessa Giselle | Girl in Gemma's Bed
(uncredited) |
| Vanessa Sheri | Crow Eater
(uncredited) |
| Natalie Skyy | Olsen Twin
(uncredited) |