| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Wayne Unser
(credit only) |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston
(credit only) |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Danny Trejo | Romero 'Romeo' Parada |
| Ray McKinnon | Lincoln 'Linc' Potter /
Gabe Marcel /
Nick Stackhouse |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| David Rees Snell | Agent Grad Nicholas |
| Benito Martinez | Luis Torres |
| Lobo Sebastian | Armando |
| Rolando Molina | Benny |
| Brian Goodman | Huff |
| Merle Dandridge | Rita Roosevelt |
| John Bishop | Reggie |
| Frank Potter | Eric Miles |
| Chris Reed | Philip 'Filthy Phil' Russell
(as Christopher Douglas Reed) |
| Cae Collmar | Tweaker Girl
(as Cae Camille) |
| Burton Perez | SAMTAZ Member |
| Ella Allan | Baby Thomas Teller
(uncredited) |
| Mia Allan | Baby Thomas Teller
(uncredited) |
| Kyle Samples | Achey
(uncredited) |
| Lee Stone | SAMTAZ Member
(uncredited) |
| Kurt Sutter | Otto 'Big Otto' Delaney
(uncredited) |