| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Chief Wayne Unser |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ally Walker | Agent June Stahl |
| Kenny Johnson | Herman Kozik |
| Paula Malcomson | Maureen Ashby |
| Titus Welliver | James 'Jimmy' O'Phelan |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Jeff Kober | Jacob Hale, Jr. |
| Jose Pablo Cantillo | Hector Salazar |
| James Cosmo | Father Kellan Ashby |
| Zoe Boyle | Trinity Ashby |
| Q'orianka Kilcher | Kerrianne Telford |
| Joel Tobeck | Donny |
| David Labrava | Happy Lowman |
| McNally Sagal | Margaret Murphy |
| Marcos A. Ferraez | Agent Estevez
(as Marcos De La Cruz) |
| Bellina Logan | Fiona Larkin |
| Pamela Gray | Agent Amy Tyler
(as Pamela J. Gray) |
| Olivia Burnette | Homeless Woman |
| Bart McCarthy | Declan Brogan |
| Paul Collins | Peter Dooley |
| Bob McCracken | Brendan Roarke |
| Marya Delver | Officer Eglee |
| Dan Hildebrand | Sean Casey |
| Tara Macken | Luisa |
| Nicholas Guest | Voice of John Teller
(voice) |
| Matthew Alan | Mark Petrie |
| Lilly McDowell | Katey Petrie |
| Dinah Lenney | Sister Miriam |
| Mike Pfaff | Orphanage Guard |
| Ben Alagna | Bellhop
(uncredited) |
| Dawn Alden | Orphanage Nun
(uncredited) |
| Christie Lynn Peterson | Club Girl
(uncredited) |
| Chris Reed | Filthy Phil
(uncredited) |
| Katherine Joan Taylor | Laurie Allen
(uncredited) |