| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Dayton Callie | Chief Wayne Unser
(credit only) |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz
(credit only) |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Kenny Johnson | Herman Kozik |
| Paula Malcomson | Maureen Ashby |
| Emilio Rivera | Marcus Alvarez |
| Michael Ornstein | Chuck 'Chucky' Marstein
(as Michael Marisi Ornstein) |
| Jose Pablo Cantillo | Hector Salazar |
| Titus Welliver | James 'Jimmy' O'Phelan |
| James Cosmo | Father Kellan Ashby |
| Taryn Manning | Rita 'Cherry' Zambell |
| Andy McPhee | Keith 'McGee' McGee
(as Andrew McPhee) |
| Arie Verveen | Liam O'Neill |
| Zoe Boyle | Trinity Ashby |
| Darin Heames | Seamus Ryan |
| Joel Tobeck | Donny |
| David Labrava | Happy Lowman |
| Dan Hildebrand | Sean Casey |
| Bart McCarthy | Declan Brogan |
| McNally Sagal | Margaret Murphy |
| Paul Collins | Peter Dooley |
| Bob McCracken | Brendan Roarke |
| Frank Potter | Miles |
| Chris Reed | Filthy Phil
(as Christopher Reed) |
| Tara Macken | Luisa |
| Michelle Diaz | Diana Alvarez |
| Dan Conroy | Timothy |
| Gregory Allen Gabroy | Officer Brown
(uncredited) |
| Chris Jorie | IRA Thug
(uncredited) |
| Brendan Kelly | IRA Thug
(uncredited) |
| Mickey Mason | Biker
(uncredited) |
| Christie Lynn Peterson | Club Girl
(uncredited) |