| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| Johnny Lewis | Kip 'Half Sack' Epps |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ally Walker | Agent June Stahl |
| Adam Arkin | Ethan Zobelle |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Dayton Callie | Chief Wayne Unser |
| Mitch Pileggi | Ernest Darby |
| Jamie McShane | Cameron Hayes |
| Callard Harris | Edmond Hayes |
| Sarah Jones | Polly Zobelle |
| Jeff Kober | Jacob Hale, Jr. |
| Henry Rollins | AJ Weston |
| Julie Ariola | Mary Winston |
| Marcos A. Ferraez | Agent Estevez
(as Marcos De La Cruz) |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Joey Anaya | Elian Perez |
| Cleo King | Neeta
(uncredited) |