| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Tom Everett Scott | Rosen |
| Ally Walker | Agent June Stahl |
| Drea de Matteo | Wendy Case |
| Ryan Hurst | Harry 'Opie' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| William Lucking | Piermont 'Piney' Winston |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Dayton Callie | Chief Wayne Unser |
| Keir O'Donnell | Lowell Harland, Jr. |
| Glenn Plummer | Sheriff Vic Trammel |
| Tory Kittles | Laroy Wayne |
| Patrick St. Esprit | Elliott Oswald |
| Julie Ariola | Mary Winston |
| Olivia Burnette | Homeless Woman |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Ashley Monique Clark | Eviqua Michaels |
| E.R. Ruiz | Gill
(as E.R) |
| Nika Patrice | Bartender
(as Annika P. Smith) |
| Andrew E. Wheeler | Father Grohl
(as Andrew Wheeler) |
| Nicholas Guest | John Teller
(voice) (uncredited) |
| Tyler Silva | Abel
(uncredited) |