| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson
(credit only) |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps
(credit only) |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Drea de Matteo | Wendy Case |
| Ally Walker | Agent June Stahl |
| Ryan Hurst | Harry 'Opie' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| William Lucking | Piermont 'Piney' Winston |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Sprague Grayden | Donna Winston |
| Dayton Callie | Chief Wayne Unser |
| Emilio Rivera | Marcus Alvarez |
| Dendrie Taylor | Luann Delaney |
| Keir O'Donnell | Lowell Harland, Jr. |
| Tory Kittles | Laroy Wayne |
| Derwin Jordan | Agent Smith |
| Julie Ariola | Mary Winston |
| Olivia Burnette | Homeless Woman |
| Marcos A. Ferraez | Agent Estevez
(as Marcos De La Cruz) |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Ashley Monique Clark | Eviqua Michaels |
| Bjorn Johnson | Doctor |
| Margot Demeter | DOJ Admin
(uncredited) |
| Lyle Kanouse | Brenan Hefner
(archive footage) (uncredited) |
| Steven Koller | Agent Nix
(uncredited) |
| Tyler Silva | Abel
(uncredited) |