| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ally Walker | Agent June Stahl |
| Ryan Hurst | Harry 'Opie' Winston |
| William Lucking | Piermont 'Piney' Winston |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Sprague Grayden | Donna Winston |
| Dayton Callie | Chief Wayne Unser |
| Dendrie Taylor | Luann Delaney |
| Jamie McShane | Cameron Hayes |
| Taryn Manning | Rita 'Cherry' Zambell |
| David Labrava | Happy |
| Derwin Jordan | Agent Smith |
| Marcos A. Ferraez | Agent Estevez
(uncredited) |
| Lyle Kanouse | Brenan Hefner
(uncredited) |
| Steven Koller | Agent Nix
(uncredited) |
| Theo Rossi | Juan Carlos 'Juice' Ortiz
(uncredited) |
| Kurt Sutter | Otto
(uncredited) |