| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Drea de Matteo | Wendy Case |
| Ryan Hurst | Harry 'Opie' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| William Lucking | Piermont 'Piney' Winston |
| Taylor Sheridan | Deputy Chief David Hale
(as Tayler Sheridan) |
| Sprague Grayden | Donna Winston |
| Mitch Pileggi | Ernest Darby |
| Dayton Callie | Chief Wayne Unser |
| Emilio Rivera | Marcus Alvarez |
| Glenn Plummer | Sheriff Vic Trammel |
| Dendrie Taylor | Luann Delaney |
| Bob Rusch | Skeeter |
| Sherrie Rose | Emily Duncan |
| Jeff Wincott | James 'Jimmy' Cacuzza |
| James Carraway | Floyd |
| John Henry Whitaker | Truck Driver
(as John Whitaker) |
| Dakota Mitchell | Lodi Cop |
| Adrian LaTourelle | Officer Craft
(as Adrian La Tourelle) |
| Nicholas Guest | The Voice of John Teller
(voice) (as Nick Guest) |
| Ralph Nunez | Latino Teen |
| Steven Klein | Manager
(as Steve Klein) |
| Pablo Espinosa | Officer Fain |
| Omid Zader | Pakistani Clerk |
| Jennifer Kaye Evans | Woman shopping |
| Mike Cochrane | Biker in Bible Study Class
(uncredited) |
| Kelly Galindo | Widow
(uncredited) |
| Cameron Goodman | Louise Hoffman
(uncredited) |
| Tory Kittles | Laroy
(uncredited) |
| Jason Rodriguez | Hot Rod Driver
(uncredited) |
| Craig Seitz | Devil's Tribe member
(uncredited) |
| Robyn Jean Springer | Crow-Eater Biker Chick
(uncredited) |
| Tony Swift | Biker
(uncredited) |