| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Isidora Goreshter | Svetlana Fisher |
| Richard Flood | Ford |
| Becca Blackwell | Father Murphy |
| Laura Cerón | Celia Delgado
(as Laura Ceron) |
| Alicia Coppola | Sue |
| Fiona Dourif | Tabitha Youens |
| Elliot Fletcher | Trevor |
| Samantha Hanratty | Kassidi
(as Sammi Hanratty) |
| Richard Herd | Gerald |
| Jessica Szohr | Nessa |
| Peter Banifaz | Farhad |
| Michael Gambino | Rodney |
| Stacey Oristano | Trina |
| Billy 'Sly' Williams | Linc |
| Troy Blendell | Ben |
| Mara Casey | Anna |
| Wardell Julius Clark | Deputy Keith
(as Wardell Clark) |
| Elena Evangelo | Voula |
| Emily Happe | Wendy |
| Christian Isaiah | Liam Gallagher |
| P.J. Johal | John
(as PJ Johal) |
| Erika T. Johnson | Di |
| Alison Livas | Alice
(as Alison Kendre Livas) |
| Lana McKissack | Lynn |
| J.D. Phillips | Jack |
| Paul Oakley Stovall | Shane |
| Shannon Mitrovich | Ian's Follower
(uncredited) |
| Paris Newton | Baby Franny
(uncredited) |