| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher
(credit only) |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Isidora Goreshter | Svetlana |
| June Squibb | Etta |
| Sharon Lawrence | Margo |
| Elliot Fletcher | Trevor |
| Pasha D. Lychnikoff | Yvon
(as Pasha Lychnikoff) |
| Ruby Modine | Sierra |
| Arden Myrin | Dollface Dolores |
| Zack Pearlman | Neil |
| Alan Rosenberg | Professor Youens |
| Van Epperson | Guidance Counselor |
| Chet Hanks | Charlie |
| Jim Hoffmaster | Kermit |
| Lela Lee | Lenore |
| Michael Patrick McGill | Tommy |
| Jennifer Taylor | Anne Seery |
| Ilia Volok | Vlad |
| Richard Augustine | Greg |
| Erin Barnes | Parent |
| Erin Callahan | Female Customer |
| Hermie Castillo | Teacher |
| Harley Cunningham | New Ian |
| Nicole Dele | Terry
(as Nicole O. Dele) |
| Andrea Ellsworth | Didi |
| Cooper J. Friedman | Lucas
(as Cooper Friedman) |
| Chiquita Fuller | Yolanda |
| Alyssa Garcia | Gina |
| Rhyan Hill | Older Kid |
| Jonah Hwang | New Lip |
| Mary E. Kennedy | New Fiona |
| Nthenya Ndunda | Noelle |
| Richard Pierre-Louis | Willie |
| Brenden Sims | Liam |
| A.C. Smith | Janitor |
| Jae'Lyn Ayauna Godoy | Pregnant Teen
(uncredited) |
| Donald Lee Holland Jr. | Customer
(uncredited) |
| Lotus Plummer | Jemma /
Amy Ball
(uncredited) |
| Christina Veronica | Dollface's friend
(uncredited) |