| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Isidora Goreshter | Svetlana |
| Jenica Bergere | Lisa |
| Alicia Coppola | Sue |
| Elliot Fletcher | Trevor |
| Pasha D. Lychnikoff | Yvon
(as Pasha Lychnikoff) |
| Peter Macon | Dominique's Father |
| Ruby Modine | Sierra |
| Alan Rosenberg | Professor Youens |
| Khleo Thomas | Dylan Oswald |
| Rebecca Metz | Melinda |
| Jaylen Barron | Dominique |
| Kahyun Kim | Melody |
| Shelley Robertson | Officer Dawson |
| Ser Anzoategui | Rabbit
(as Karen Anzoategui) |
| Allison Bills | Bonnie |
| Greg Berney | Max |
| Shannon Brown | New Debbie
(as Shannon Merrill Brown) |
| Paul Culos | Joe |
| Derek Dziak | Mentally Ill Man |
| Andrea Ellsworth | Didi |
| Judie Garcia | Reporter |
| Cheyenne Haynes | Bethany |
| Jonah Hwang | New Lip |
| Rod Keller | Emerson |
| Mary E. Kennedy | New Fiona |
| Josh McCrary | New Carl
(as Joshua McCrary) |
| Courtney McCullough | DX |
| Barry Papick | Alderman |
| Ty Quiamboa | Swastika Dude |
| Brenden Sims | Liam |
| Sean Spann | Aggravated Neighbor |
| Dan Thiel | Beefy Fed |
| Michael Timlin | Drunk Punk |
| Suteara Vaughn | Ariel |
| Christopher Arminio | Alibi Hipster
(uncredited) |
| Shelbe Chang | Server
(uncredited) |
| Giota Trakas | El Passenger
(uncredited) |
| Alex Zelenka | Pedestrian
(uncredited) |