| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Noel Fisher | Mickey Milkovich |
| Emily Bergl | Sammi Slott |
| Dermot Mulroney | Sean Pierce |
| Sasha Alexander | Helene Runyon |
| Michael Reilly Burke | Theo Wallace |
| José Julián | Joaquin
(as Jose Julian) |
| Bojana Novakovic | Bianca Samson |
| Michael B. Silver | Lorenzo |
| Shani Atias | Stacey |
| Tessa Auberjonois | Kendra |
| Matt Bennett | Wiley |
| Roxana Brusso | Judge Rita Gaither |
| Lawrence A. Mandley | Sam Rayburn
(as Lawrence Mandley) |
| Rebecca Metz | Melinda |
| Rena Strober | Emily Knowland |
| Troy A. Cephers | Bailiff
(as Troy Cephers) |
| Brad Einstein | Yaz |
| Ryan G. Roberts | Skinhead
(as Ryan Robert Garcia) |
| Nigel Joaquin | Andre |
| Kellen Michael | Chuckie Slott |
| Garrett Reese | Ben |
| Adrienne Rusk | Daisy Kelso |
| Peter Coventry Smith | Trevor |
| Afton Boggiano | Michelle
(uncredited) |
| Matthew Salter | CTA Train Bystander
(uncredited) |
| Brenden Sims | Liam Gallagher
(uncredited) |