| William H. Macy | Frank Gallagher |
| Emmy Rossum | Fiona Gallagher |
| Jeremy Allen White | Lip Gallagher |
| Ethan Cutkosky | Carl Gallagher |
| Shanola Hampton | Veronica Fisher |
| Steve Howey | Kevin Ball |
| Emma Kenney | Debbie Gallagher |
| Cameron Monaghan | Ian Gallagher |
| Noel Fisher | Mickey Milkovich |
| Emma Greenwell | Mandy Milkovich |
| Emily Bergl | Sammi Slott |
| Wendy Phillips | Professor Sacco |
| Lisa Vidal | Maria Vidal |
| Isidora Goreshter | Svetlana |
| James Allen McCune | Matty Baker |
| Nichole Sakura | Amanda
(as Nichole Bloom) |
| Edward Edwards | Mark |
| Denise Grayson | Judge Kaitlin Shanor |
| Will Green | Howie |
| Gregory Linington | Craig Jeffries |
| Jayden Lund | Scott |
| Karen Maruyama | Dr. Ma |
| Michael Patrick McGill | Tommy |
| Teresa Ornelas | Ellie |
| Danika Yarosh | Holly Herkimer |
| Dmitri S. Boudrine | SUV Driver
(as Dmitri Boudrine) |
| Zylan Brooks | Court Clerk |
| Thai Edwards | Bouncer |
| Joshua Hoffman | Les |
| Jim Hoffmaster | Kermit |
| Miguel Izaguirre | Paco |
| Sam Kindseth | Fiore |
| Stuart McLean | Spencer |
| Kellen Michael | Chuck |
| Rene Moran | Jairo
(as Rene D. Moran) |
| Brenden Sims | Liam Gallagher |
| Jordan Orr | Punk Kid
(as Jordan Del Spina) |
| Abram Teunissen | Wolf |
| Michael John Benzaia | Go-Go Dancer
(uncredited) |
| Sean Bresnahan | Sleazy Bar Patron
(uncredited) |
| Christopher Clausi | Lawyer
(uncredited) |
| Mike Cochrane | Alibi Bar Regular
(uncredited) |
| W. Lee Hill | Bailiff
(uncredited) |
| Shawn Hoffman | Michael
(uncredited) |
| Jade Holden | Middle School Student
(uncredited) |
| Lisa Pevc | Convict
(uncredited) |
| Louis Scherschel | Club Goer
(uncredited) |
| Frankie Sims | Alibi Bar Patron
(uncredited) |