| Patrick Stewart | Capt. Jean-Luc Picard |
| Jonathan Frakes | Cmdr. William Riker |
| LeVar Burton | Lt. Cmdr. Geordi La Forge |
| Michael Dorn | Lt. Worf |
| Gates McFadden | Dr. Beverly Crusher |
| Marina Sirtis | Counselor Deanna Troi |
| Brent Spiner | Lt. Cmdr. Data
(credit only) |
| Wil Wheaton | Ensign Wesley Crusher |
| Jeremy Kemp | Robert Picard |
| Samantha Eggar | Marie Picard |
| Theodore Bikel | CPO Sergey Rozhenko, ret. |
| Georgia Brown | Helena Rozhenko |
| Dennis Creaghan | Louis |
| Colm Meaney | Chief Miles O'Brien |
| Whoopi Goldberg | Guinan |
| David Birkin | René Picard
(as David Tristan Birkin) |
| Doug Wert | Jack Crusher |
| Majel Barrett | Enterprise Computer
(archive sound) (uncredited) |
| Elliot Durant III | Starfleet Ensign
(uncredited) |