| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Amaury Nolasco | Fernando Sucre |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| Peter Stormare | John Abruzzi |
| Michelle Forbes | Samantha Brinker |
| John Heard | Governor Frank Tancredi |
| Lane Garrison | David 'Tweener' Apolskis |
| Silas Weir Mitchell | Charles 'Haywire' Patoshik |
| Joe Nunez | Manche Sanchez |
| John Billingsley | Terrence Steadman |
| Frank Grillo | Nick Savrinn |
| Patricia Wettig | Vice President Caroline Reynolds |
| Stacy Keach | Warden Henry Pope |
| Christian Stolte | Corrections Officer Keith Stolte |
| Phillip Edward Van Lear | Louis Patterson |
| Mac Brandt | Corrections Officer Mack Andrews Andrews |
| Mark Morettini | C.O. Rizzo Green |
| Javon Johnson | C.O. JJ |
| DuShon Monique Brown | Nurse Katie Welch |
| Jennifer Joan Taylor | Becky |
| Rich Komenich | Maggio |
| Kurt Naebig | C.O. Ray |
| Lester Kevin Senor | C.O. Kevin |
| David Alan Anderson | Orderly |
| T.J. Jagodowski | Pilot |
| Doug James | Air Strip Controller |
| James Farruggio | Secret Service Agent at Press Conference |
| Coburn Goss | Special Services Investigator |
| Steve Haggard | Sweats |
| Reese Madigan | Secret Service Man At Hotel |
| James Leaming | Agent In Charge At Hotel |
| Brian McCaskill | Peter - Reporter |
| Ilyssa Fradin | Rebecca - Female Reporter |
| Robin Robinson | TV Reporter |
| Craig Spidle | District Judge |
| Greg Sandquist | Cop #3 at Sara's |
| Patrick Clear | Deadly Solution Man #1 |
| Raymond L. Chapman | Deadly Solution Man #2 |
| Sam Zerante | Farmer |
| Samantha Scarpelli | Bike Girl |
| Brent Allen Caputo | K-9 Unit Officer |
| Bob Fanucchi | Auto Shop Manager |
| Randall Jones | Reporter |
| Zachary Laoutides | Prisoner |
| Danny McCarthy | Daniel Hale |
| Jim Moore | Sheriff |
| Joseph A Olivera | Secret Service Agent |
| John Stacho | County Sheriff K-9 |
| January Stern | News Reporter |
| Marco Tazioli | Waiter |