| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Amaury Nolasco | Fernando Sucre |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Sarah Wayne Callies | Sara Tancredi |
| Muse Watson | Charles Westmoreland |
| Peter Stormare | John Abruzzi |
| Frank Grillo | Nick Savrinn |
| Lane Garrison | David 'Tweener' Apolskis |
| Holly Valance | Nika Volek |
| Joe Nunez | Manche Sanchez |
| Tony Denison | Aldo Burrows |
| John Billingsley | Terrence Steadman |
| Patricia Wettig | Vice President Caroline Reynolds |
| Stacy Keach | Warden Henry Pope |
| Daniel Allar | Avocado |
| DuShon Monique Brown | Nurse Katie Welch |
| Phillip Edward Van Lear | Louis Patterson |
| Christian Stolte | Corrections Officer Keith Stolte |
| Will Zahrn | Sheriff Nathan Ballard |
| Wesley Walker | Crony |
| Scott Westerman | Maintenance Guy |
| Cliff Frazier | Orderly |
| Lester Kevin Senor | C.O. Kevin |
| Melissa Chirello-Wood | Prisoner's Wife Visiting |
| Zachary Laoutides | Prisoner |
| Jonathan Samuels | Inmate |
| George Wood | Inmate |