| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Amaury Nolasco | Fernando Sucre |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Sarah Wayne Callies | Sara Tancredi |
| Michelle Forbes | Samantha Brinker |
| Danny McCarthy | Daniel Hale |
| Camille Guaty | Maricruz Delgado |
| Mike Jones | Darius |
| Kurt Caceres | Hector Avila |
| Joe Nunez | Manche Sanchez |
| Joseph Sikora | Sara's boyfriend |
| John Billingsley | Terrence Steadman |
| K.K. Dodds | Susan Hollander |
| Patricia Wettig | Vice President Caroline Reynolds |
| John Walsh | Self - Presenter of America's Most Wanted |
| Tab Baker | Crab Simmons |
| Jason Wells | Bo |
| Cynthia Kaye McWilliams | Kacee Franklin |
| Helena Klevorn | Dede Franklin |
| Jay Whittaker | Commander Meyers |
| Danielle Campbell | Gracey Hollander |
| Miguel Nino | Coyote |
| Anthony Moseley | Junior Executive |
| Joe Van Slyke | Judge |
| Dale Rivera | Conspirator |
| Janelle Holmgren | Delivery Girl |
| Quinn Wermeling | Zack Hollander |
| Carl Amari | Liquor Store Clerk |
| John Ferrick | Foreperson |
| Thomas Gaitsch | Media Guy |
| Anne Jacques | Onlooker |
| Kyle Hatley | Resident |
| Jeremy Isaiah Earl | Soldier #1 |
| Max Kirsch | Young Lincoln Burrows |
| Dylan Minnette | Young Michael |
| Annie Yokom | Young Veronica Donovan |
| Sam Derence | ND Suit |
| Adeoye Mabogunje | Soldier with $100 Bill |
| Brent Allen Caputo | Courtroom Attendee |
| Angela Cobb | Office Executive |
| Will Jones | (uncredited) |
| Tim Krueger | Secret Service Agent |
| Zachary Laoutides | Prisoner |
| Jim Moore | Vendor at Baseball Game |
| Haley Nero | Child in the Field |
| Lindsey Nero | Prison Visitor |
| Angelina Riposta | Accident Scene Pedestrian |
| John Stacho | Desert Storm soldier |
| John Thurston | Man in Baseball Field |
| Joyce Thurston | Baseball Field Patron |
| Giota Trakas | Accident Witness |
| Zachary Uidl | Police Officer |