| Dominic Purcell | Lincoln 'Linc' Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Peter Stormare | John Abruzzi |
| Amaury Nolasco | Fernando Sucre |
| Wade Williams | Brad Bellick |
| Paul Adelstein | Paul Kellerman |
| Sarah Wayne Callies | Sara Tancredi |
| Frank Grillo | Nick Savrinn |
| Muse Watson | Charles Westmoreland |
| Danny McCarthy | Daniel Hale |
| Stacy Keach | Warden Henry Pope |
| Peter J. Reineman | Gus Fiorello |
| Deanna Dunagan | Judy Pope |
| Dylan Minnette | Young Michael |
| Max Kirsch | Young Lincoln Burrows |
| Alan Wilder | Reverend Mailor |
| Mac Brandt | Corrections Officer Mack Andrews Andrews |
| Phillip Edward Van Lear | Louis Patterson |
| Christian Stolte | Corrections Officer Keith Stolte |
| Jennifer Joan Taylor | Becky |
| DuShon Monique Brown | Nurse Katie Welch |
| Joe Minoso | Chaz Fink |
| Jane Galloway Heitz | Uppity Clerk |
| Mark Morettini | Correctional Officer Rizzo Green |
| Jason Frederick | CO |
| Michael L. Howard | Inmate |
| Tim Krueger | Dad |
| Zachary Laoutides | Prisoner |
| William Nero Sr. | Police Officer |
| Lindsey Nero | Prison Visitor |
| Patricia Wettig | Menacing Woman in Kitchen |