| Kirk Acevedo | Miguel Alvarez |
| Ernie Hudson | Warden Leo Glynn
(credit only) |
| Terry Kinney | Tim McManus |
| Rita Moreno | Sister Peter Marie Reimondo |
| Harold Perrineau | Augustus Hill |
| J.K. Simmons | Vern Schillinger |
| Lee Tergesen | Tobias Beecher |
| Dean Winters | Ryan O'Reily |
| Mason Adams | Mr. Hoyt |
| Betty Buckley | Suzanne Fitzgerald |
| Robert John Burke | Special Agent Pierce Taylor |
| Bobby Cannavale | Alonzo Torquemada |
| Reg E. Cathey | Martin Querns |
| Anthony Chisholm | Burr Redding |
| Kevin Conway | Seamus O'Reilly |
| Rick Fox | Jackson Vahue |
| Joel Grey | Lemuel Idzik |
| Zeljko Ivanek | Governor James Devlin |
| Simon Jones | Judge Mason Kessler |
| Patti LuPone | Stella Coffa |
| Christopher Meloni | Chris Keller |
| George Morfogen | Bob Rebadow |
| Luna Lauren Velez | Dr. Gloria Nathan
(as Lauren Vélez) |
| Scott William Winters | Cyril O'Reily |
| BD Wong | Father Ray Mukada |
| Granville Adams | Zahir Arif |
| Becky Ann Baker | Greta |
| Robert Clohessy | Officer Sean Murphy |
| Roxanne Hart | Jessica Kirk |
| Peter Francis James | Jahfree Neema |
| Tom Mardirosian | Agamemnon Busmalis |
| Ellen McElduff | Eleanor O'Connor |
| Craig muMs Grant | Poet
(as muMs) |
| R.E. Rodgers | James Robson |
| Kristin Rohde | Officer Claire Howell |
| Otto Sanchez | Chico Guerra |
| Chuck Zito | Chucky Pancamo |
| Andrea Anders | Donna Degenhart |
| Joseph Aro | Altar Boy |
| Jerome Preston Bates | Officer Travis Smith |
| Peter Hans Benson | Reporter
(as Peter Benson) |
| Timothy L. Brown | Officer Jason Armstrong |
| Michael J. Burg | Andenaur |
| Don Cebron | Correction Officer |
| Marilyn Chris | Oppenheimer |
| Antoni Corone | Frank 'The Fixer' Urbano
(as Antoni Cornacchione) |
| Marta Critelli | Nurse |
| Bill Dawes | |
| Carl DiMaggio | Officer Len Lopresti |
| Sean Dugan | Timmy Kirk |
| Todd Etelson | Mario Seggio |
| Cyrus Farmer | Officer Adrian Johnson |
| Mtume Gant | Reggie Rawls |
| Jay Harris | Douglas |
| Andrew Heckler | Behn |
| Tony Hoty | Lionel Kelsch |
| Chris Jackson | Perry Loftus
(as Christopher Neal Jackson) |
| Steven Johnson | Prisoner |
| Raymond Michael Karl | Officer |
| Conrad Lindsay | Muslim |
| John Lurie | Greg Penders |
| Malik | Kenaniah Maxwell |
| Mark Mineart | Weapons Officer |
| Gary Perez | Luis Ruiz |
| Calvin Powell | Prisoner |
| Amie Quigley | Cathy Jo Cutler |
| Michael Rivera | Pablo Rosa |
| Blake Robbins | Officer Dave Brass |
| Luis Rodriguez | Prisoner |
| Philip Scozzarella | Officer Joseph Mineo
(as Philip V. Scozzarella) |
| Evan Seinfeld | Jaz Hoyt |
| Casey Siemaszko | Detective Tarnowski |
| Lawrence Cameron Steele | Aryan |
| Hank Wagner | Stein |
| Thomas G. Waites | Henry Stanton |
| Eric Floyd | Unit B Aryan
(uncredited) |
| Joe James | Arian Inmate
(uncredited) |
| Edgar Nicholson | Muslim Inmate
(uncredited) |
| Jack Shamblin | Arian Brother
(uncredited) |
| Peter Steele | Prisoner
(uncredited) |
| Steven Wishnoff | Tony Masters
(uncredited) |