| Adewale Akinnuoye-Agbaje | Simon Adebisi |
| Ernie Hudson | Warden Leo Glynn |
| Terry Kinney | Tim McManus |
| Rita Moreno | Sister Peter Marie Reimondo |
| Harold Perrineau | Augustus Hill |
| J.K. Simmons | Vern Schillinger |
| Lee Tergesen | Tobias Beecher |
| Eamonn Walker | Kareem Said |
| Dean Winters | Ryan O'Reily |
| Robert John Burke | Special Agent Pierce Taylor |
| Reg E. Cathey | Martin Querns |
| Kathryn Erbe | Shirley Bellinger |
| Zeljko Ivanek | Governor James Devlin |
| David Johansen | Eli Zabitz |
| Gavin MacLeod | Cardinal Frances Abgott |
| Christopher Meloni | Chris Keller |
| George Morfogen | Bob Rebadow |
| Luna Lauren Velez | Dr. Gloria Nathan |
| BD Wong | Father Ray Mukada |
| Granville Adams | Zahir Arif |
| Robert T. Bogue | Jason Cramer |
| Richard Bright | Detective Robert Stransky |
| Charles Busch | Nat Ginzburg |
| Philip Casnoff | Nikolai Stanislofsky |
| Robert Clohessy | Officer Sean Murphy |
| Seth Gilliam | Clayton Hughes |
| Erik King | Moses Deyell |
| Edward Herrmann | Harrison Beecher |
| Kathleen Widdoes | Mrs. Beecher |
| Tom Mardirosian | Agamemnon Busmalis |
| Craig muMs Grant | Poet |
| Dana Reeve | Wendy Schultz |
| Kristin Rohde | Officer Claire Howell |
| Scott William Winters | Cyril O'Reily |
| David Zayas | Enrique Morales |
| Andrew Barchilon | Hank Schillinger |
| Timothy L. Brown | Officer Jason Armstrong |
| Carl DiMaggio | Officer Len Lopresti |
| Sean Dugan | Timmy Kirk |
| Michael Patrick McCaffrey | Jesus |
| Michael Quill | Mark Miles |
| Lance Reddick | Desmond Mobay |
| R.E. Rodgers | James Robson |
| Otto Sanchez | Chico Guerra |
| Philip Scozzarella | Officer Joseph Mineo |
| Evan Seinfeld | Jaz Hoyt |
| Chuck Zito | Chucky Pancamo |
| Frank Bonsangue | Sicilian Crew |
| Vincent D'Arbouze | Vincent |
| Charles S. Dutton | Alvah Case |
| Jeff Patterson | Inmate |
| Steven Wishnoff | Tony Masters |