| Kirk Acevedo | Miguel Alvarez |
| Adewale Akinnuoye-Agbaje | Simon Adebisi |
| Ernie Hudson | Warden Leo Glynn |
| Terry Kinney | Tim McManus
(credit only) |
| Rita Moreno | Sister Peter Marie Reimondo |
| Harold Perrineau | Augustus Hill |
| J.K. Simmons | Vern Schillinger |
| Lee Tergesen | Tobias Beecher |
| Eamonn Walker | Kareem Said |
| Dean Winters | Ryan O'Reily |
| Kathryn Erbe | Shirley Bellinger |
| Luis Guzmán | Raoul 'El Cid' Hernandez |
| Zeljko Ivanek | Governor James Devlin |
| Dana Ivey | Patricia Nathan |
| Simon Jones | Judge Mason Kessler |
| John McMartin | Lars Nathan |
| Christopher Meloni | Chris Keller |
| George Morfogen | Bob Rebadow |
| Luna Lauren Velez | Dr. Gloria Nathan
(as Lauren Vélez) |
| BD Wong | Father Ray Mukada |
| Granville Adams | Zahir Arif |
| Arija Bareikis | Tricia Ross |
| Robert T. Bogue | Jason Cramer
(as Robert Bogue) |
| Charles Busch | Nat Ginzburg |
| Philip Casnoff | Nikolai Stanislofsky |
| Robert Clohessy | Officer Sean Murphy |
| Michael Gaston | Zeke Bellinger |
| Seth Gilliam | Clayton Hughes |
| Erik King | Moses Deyell |
| Tom Mardirosian | Agamemnon Busmalis |
| Craig muMs Grant | Poet
(as muMs) |
| Dana Reeve | Wendy Schultz |
| Kristin Rohde | Officer Claire Howell |
| Scott William Winters | Cyril O'Reily |
| David Zayas | Enrique Morales |
| Andrew Barchilon | Hank Schillinger |
| Timothy L. Brown | Officer Jason Armstrong |
| Carl DiMaggio | Officer Len Lopresti |
| Sean Dugan | Timmy Kirk |
| Todd Etelson | Mario Seggio |
| Oni Faida Lampley | Rev. Truman |
| Michael Pemberton | Officer Staples |
| Clarke Peters | Afsana |
| Larry Pine | Arnie Zelman |
| Michael Quill | Mark Miles |
| Lance Reddick | Desmond Mobay |
| R.E. Rodgers | James Robson |
| Otto Sanchez | Chico Guerra |
| Philip Scozzarella | Officer Joseph Mineo
(as Philip V. Scozzarella) |
| Evan Seinfeld | Jaz Hoyt |
| Danton Stone | D.A. Pat Fortunato |
| Chuck Zito | Chucky Pancamo |
| Whitney Allen | Miss Sally
(uncredited) |
| Frank Bonsangue | Sicilian Crew
(uncredited) |
| Steven Wishnoff | Tony Masters
(uncredited) |