| Kirk Acevedo | Miguel Alvarez |
| Ernie Hudson | Warden Leo Glynn |
| Terry Kinney | Tim McManus |
| Rita Moreno | Sister Peter Marie Reimondo |
| Harold Perrineau | Augustus Hill |
| J.K. Simmons | Vern Schillinger |
| Lee Tergesen | Tobias Beecher |
| Eamonn Walker | Kareem Said |
| Dean Winters | Ryan O'Reily |
| Adewale Akinnuoye-Agbaje | Simon Adebisi |
| Edie Falco | Officer Diane Whittlesey |
| George Morfogen | Bob Rebadow |
| Luna Lauren Velez | Dr. Gloria Nathan
(as Lauren Velez) |
| BD Wong | Father Ray Mukada |
| Eddie Malavarca | Peter Schibetta |
| Granville Adams | Zahir Arif |
| J.D. Williams | Kenny Wangler |
| Craig muMs Grant | Poet
(as muMs) |
| Tom Mardirosian | Agamemnon Busmalis |
| Bryan Callen | Jonathan Coushaine |
| Adrienne Shelly | Sarah |
| Dick Boccelli | Heinrick Schillinger
(as Dick Bocelli) |
| Leif Riddell | Mark Mack |
| Sean Dugan | Timmy Kirk |
| Chuck Zito | Chucky Pancamo |
| Frank Senger | Frank Manhardt |
| Jordan Lage | Richie Hanlon |
| Philip Scozzarella | Officer Joseph Mineo
(as Philip V. Scozzarella) |
| Timothy L. Brown | Officer Jason Armstrong
(as Tim Brown) |
| Todd Etelson | Mario Seggio |
| Ali Merhi | Luis Batista |
| Carlos Antonio | Rapist
(uncredited) |
| Frank Bonsangue | Sicilian Crew
(uncredited) |
| Douglas Crosby | Officer D'Agnasti
(uncredited) |
| Brett Gillen | Philip Featherstone
(uncredited) |
| Nick Stellate | Prisoner in Gym
(uncredited) |