| Taylor Schilling | Piper Chapman |
| Laura Prepon | Alex Vause |
| Michael Harney | Sam Healy |
| Michelle Hurst | Miss Claudette Pelage |
| Kate Mulgrew | Galina 'Red' Reznikov |
| Jason Biggs | Larry Bloom |
| David Aaron Baker | Tim |
| Danielle Brooks | Tasha 'Taystee' Jefferson |
| Laverne Cox | Sophia Burset |
| Jackie Cruz | Marisol 'Flaca' Gonzales |
| Joel Marsh Garland | Scott O'Neill |
| Annie Golden | Norma Romano |
| Diane Guerrero | Maritza Ramos |
| Patricia Kalember | Marka Nichols |
| Lauren Lapkus | Susan Fischer |
| Natasha Lyonne | Nicky Nichols |
| Taryn Manning | Tiffany 'Pennsatucky' Doggett |
| Matt McGorry | John Bennett |
| Elizabeth Rodriguez | Aleida Diaz |
| Deborah Rush | Carol Chapman |
| Nick Sandow | Joe Caputo |
| Samira Wiley | Poussey Washington |
| Pablo Schreiber | George 'Pornstache' Mendez |
| Uzo Aduba | Suzanne 'Crazy Eyes' Warren |
| Madeline Brewer | Tricia Miller |
| Lori Tan Chinn | Mei Chang |
| Berto Colon | Cesar |
| Catherine Curtin | Wanda Bell |
| Lea DeLaria | Big Boo |
| Maria Dizzia | Polly Harper |
| Laura Gómez | Blanca Flores |
| Nora Hummel | Chaya |
| Sebastian La Cause | Fahri |
| Selenis Leyva | Gloria Mendoza |
| Emma Myles | Leanne Taylor |
| Michael Nathanson | Kinno |
| Jessica Pimentel | Maria Ruiz |
| Dascha Polanco | Dayanara Diaz |
| Alysia Reiner | Natalie Figueroa |
| Constance Shulman | Yoga Jones |
| Yael Stone | Lorna Morello |
| Nancy Ticotin | Lola Diaz |
| Tamara Torres | Weeping Woman |
| Olya Zueva | Jamie |
| Shaleeni Ranchhod | Inmate |
| Jessica Shea Alverson | Inmate |
| James Thomas Bligh | Gynecologist |
| José Báez | El Diablo |
| Eric J Carlson | Corrections Officer |
| Elizabeth Clark | Inmate |
| Beth Katehis | Inmate |
| Carmen Torres | Inmate |
| Tricia Mary Young | Hawaiian Inmate |