| Ryan Eggold | Dr. Max Goodwin |
| Janet Montgomery | Dr. Lauren Bloom |
| Freema Agyeman | Dr. Helen Sharpe |
| Jocko Sims | Dr. Floyd Reynolds |
| Tyler Labine | Dr. Iggy Frome |
| Amaia Arana | ED Resident Roxana Zamaya |
| Andre B. Blake | Dr. Claude Baptiste |
| Ralph Brown | Sid Chiltern |
| Yadira Correa | Officer Elizondo |
| Sandra Mae Frank | Dr. Wilder |
| Katie Lee Hill | Willow Yun |
| Conner Marx | Ben Meyer |
| Patrick Murney | Nico Jerrino |
| Frances Turner | Dr. Lyn Malvo |
| Genevieve Angelson | Dr. Mia Castries |
| Raji Ahsan | Dr. Rahul Vaishya |
| Kapil Bawa | Dr. Ramchandani |
| Aadya Bedi | Dr. Aqsa Fadel |
| Maggie Benedict | Dr. Charmaine Stewart |
| Lorna Bennett | Nurse Shirley Wattles |
| Robert K. Benson | Dr. Winstanley |
| Mahnaz Damania | Dr. Narin Sadik |
| Mahalet Dejene | Anesthesiologist Nyala Abebe |
| Cameron Folmar | Dr. Griffin Cornelissen |
| Clara Francesca | Receptionist Priscilla |
| Chloe Freeman | Resident Pavan Carey |
| Keturah Hamilton | Dr. Aboqela |
| Remy Laifer | NYPD Officer Mickey Pollack |
| Teresa Patel | Paramedic Harvell |
| Nick Petito | Delivery Person 1 |
| Annie Pisapia | Agitated Woman |
| Paul Salvatoriello | Restaurant Manager |
| Ransel Sangster | Érman |
| Jennifer Betit Yen | OR Nurse Aimee Kamoe |
| Luke Young | Security Guard Bertram |
| Tam Young | Delivery Person 2 |