| Scoot McNairy | Walt Breslin |
| Luis Gerardo Méndez | Victor Tapia |
| Matt Letscher | James Kuykendall |
| Luisa Rubino | Andrea Nuñez |
| Alfonso Dosal | Benjamín Arellano Félix |
| Mayra Hermosillo | Enedina Arellano Felix |
| Manuel Masalva | Ramón Arellano Félix |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Gorka Lasaosa | Héctor Palma |
| Alejandro Furth | Ramon Salgado |
| Lorenzo Ferro | Alex Aragón |
| José Zúñiga | Rebollo |
| Bobby Soto | David Barron |
| Beau Mirchoff | Steve Sheridan |
| Joaquín Cosio | Don Neto |
| Kristen Gutoskie | Dani |
| Fermín Martínez | El Azul |
| Francisco Barreiro | Francisco Arellano Felix |
| Manuel Uriza | Carlos Hank Gonzalez |
| Sebastián Buitrón | Eduardo Arellano Felix |
| Damayanti Quintanar | Hortencia |
| Bad Bunny | Arturo 'Kitty' Paez |
| Adriana Llabres | Ruth Arellano Felix |
| Markin López | Rogelio |
| Francisco Rubio | Marcos Santos |
| Adolfo Madera | President Elect |
| Cristina Michaus | Mrs. Barragán |
| Marco Treviño | Father Baiz |
| Diego Calva | Arturo Bertrán Leyva |
| Diana Carreiro | Alma |
| Mara Cuevas | Mrs. Hodoyan |
| Sandra Celedón Esparza | Hodoyan's Maid |
| Tamara Guzmán | Chapo's Mom |
| Carlos Gatica | Fausto Soberanos |
| Odiseo Bichir | Cardinal Sandoval Iñiguez |
| Brian Espitia | Enrique |
| Erwin Berzain | Sergeant Vazquez |
| Peter Delos Reyes | Baggage Attendant |
| Jose Luis Huerta | Guatemalan Army Commander |
| Jorge Farnetti | Prison Guard |
| Leonardo D'Antoni | Bobby |
| Kevin Z. Palmer | Soldier |
| Abel Rodríguez | Soldier 2 |
| Marilú García Luna | Female Reporter |
| Juan Manuel Pavon | Male Reporter |
| Gabriela Aguirre | Female Reporter #2 |
| Camilo Beristáin | Male Reporter #2 |
| Adonay Cabrera | President's Driver |
| Darío T. Pie | Procurador Carpizo |
| Sara Manni | Mom |
| Sasha Zoé | Daughter |
| Alonso Gálvez | Custom's Agent |