| Diego Luna | Miguel Ángel Félix Gallardo |
| Scoot McNairy | Walt Breslin |
| José María Yazpik | Amado Carrillo Fuentes |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Fernanda Urrejola | María Elvira |
| Gorka Lasaosa | Héctor Palma |
| Alfonso Dosal | Benjamín Arellano Félix |
| Mayra Hermosillo | Enedina Arellano Felix |
| Andres Londono | Enrique Clavel |
| Flavio Medina | Juan García Abrego |
| Teresa Ruiz | Isabella Bautista |
| Julio Cesar Cedillo | Guillermo González Calderoni |
| Manuel Masalva | Ramón Arellano Félix |
| Alberto Ammann | Pacho Herrera |
| Fermín Martínez | El Azul |
| Juan Sebastián Calero | Navegante |
| Clark Freeman | Ed Heath |
| Nat Faxon | Ted Kaye |
| Viviana Serna | Guadalupe |
| Matt Letscher | James Kuykendall |
| Jesús Ochoa | Juan Nepomuceno Guerra |
| Francisco Barreiro | Francisco Arellano Félix |
| José Julián | Javier Arellano Félix |
| Sebastián Buitrón | Eduardo Arellano Félix |
| Mark Pinter | John Bell |
| Noé Hernández | Rafael Aguilar |
| Érick Israel Consuelo | Manny |
| Luna Beltran | Isabel Arellano Félix |
| Marilyn Uribe | Alicia María Arellano Félix |
| Mauricio Isaac | The Brother |
| Adolfo Madera | President Elect |
| DaJuan Johnson | Agent Morris |
| Derek Smith | Agent Downey |
| Esteban Caicedo | Duvan |
| Palmeira Cruz | Young Woman |
| Martín Rojas | Tijuana Police Captain |
| Jonathan Ochoa | Miguel Jr. |
| Ivana Plantier | Abril |
| Salvador Parra | Maitre D' |
| Orlando Pineda | Colombian Guy #1 |
| Teresa Cedillo | Maid |
| Katie Chan | Cashier |
| Adriana Llabres | Ruth |
| Jonathan Laredo | Fireman |
| Chris Jai Alex | Cop |
| Matthew Jones | El Paso Guy #1 |
| Scott Thomas Reynolds | El Paso Guy |