| Diego Luna | Miguel Ángel Félix Gallardo |
| Scoot McNairy | Walt Breslin |
| José María Yazpik | Amado Carrillo Fuentes |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Gorka Lasaosa | Héctor Palma |
| Fernanda Urrejola | María Elvira |
| Alfonso Dosal | Benjamín Arellano Félix |
| Manuel Masalva | Ramón Arellano Félix |
| Mayra Hermosillo | Enedina Arellano Felix |
| Teresa Ruiz | Isabella Bautista |
| Miguel Rodarte | Danilo Garza |
| Jesse Garcia | Sal Orozco |
| Matt Biedel | Daryl Petsky |
| Jero Medina | Ossie Mejía |
| Alberto Zeni | Amat Palacios |
| Julio Cesar Cedillo | Guillermo González Calderoni |
| Andres Londono | Enrique Clavel |
| Fermín Martínez | El Azul |
| Andrés Almeida | Cochiloco |
| Clark Freeman | Ed Heath |
| Julián Arango | Orlando Henao |
| Sebastián Buitrón | Eduardo Arellano Félix |
| Francisco Barreiro | Francisco Arellano Félix |
| José Julián | Javier Arellano Félix |
| Bobby Soto | David Barron |
| Viviana Serna | Guadalupe |
| Alberto Lomnitz | Cuauhtémoc Cárdenas |
| Luna Beltran | Isabel Arellano Félix |
| Marilyn Uribe | Alicia María Arellano Félix |
| María Rojo | Alicia Arellano Félix |
| Alejandra Guilmant | Daniela |
| Adriana Llabres | Ruth |
| Greg Eagles | Auctioneer |
| Mauricio Isaac | The Brother |
| Jonathan Ochoa | Miguel Jr. |
| Ivana Plantier | Abril |
| Daniel Quiróz | Iván |
| Ian Garcia Monterrubio | Younger Boy |
| Emi Lardi Delon | Older Boy |
| Nicole Reyes | Manuela |
| Alfredo Huereca | Serafín Herrera |
| Rodrigo Mendoza | Priest |
| Claudia Toledo | Old Housekeeper |