| Michael Peña | Enrique 'Kiki' Camarena |
| Diego Luna | Miguel Ángel Félix Gallardo |
| Tenoch Huerta | Rafael Caro Quintero |
| Alyssa Diaz | Mika Camarena |
| Joaquín Cosio | Ernesto 'Don Neto' Fonseca Carrillo |
| José María Yazpik | Amado Carrillo Fuentes |
| Matt Letscher | James Kuykendall |
| Ernesto Alterio | Salvador Osuna Nava |
| Alejandro Edda | Joaquín 'El Chapo' Guzmán |
| Fernanda Urrejola | María Elvira |
| Teresa Ruiz | Isabella Bautista |
| Gerardo Taracena | Pablo Acosta |
| Aaron Staton | Butch Sears |
| Fermín Martínez | El Azul |
| Horacio Garcia Rojas | Tomás Morlet |
| Edmundo Vargas | Cuco |
| Andrés Almeida | Cochiloco |
| Alfonso Dosal | Benjamín Arellano Félix |
| Manuel Masalva | Ramón Arellano Félix |
| Tessa Ia | Sofía Conesa |
| Clark Freeman | Ed Heath |
| Yul Vazquez | John Gavin |
| Guillermo Villegas | Sammy Álvarez |
| Itza Sodi | Captain Alfredo Zavala |
| Mark Kubr | Tony |
| Luis Navarro Arredondo | Gilberto |
| José Luis Pérez | Omar |
| Brian Buckley | John Walker |
| Jeff Grace | Alberto Radelat |
| Francisco Barreiro | Francisco Arellano Félix |
| Gorka Lasaosa | Héctor Palma |
| Joshua Okamoto | Manuel |
| Eric Strong | San Diego Realtor |
| Raúl Villegas | Pedro |
| Israel Salmer | Pilot |
| Noel León | Drunk |
| Fernando Ransom de la Torre | Juan |
| Pedro Hernández | Paco |
| Alessandro Borrelli | Kiki Jr. |
| Scoot McNairy | Narrator |