| Mike Colter | Luke Cage |
| Simone Missick | Misty Knight |
| Theo Rossi | Hernan 'Shades' Alvarez |
| Erik LaRay Harvey | Willis 'Diamondback' Stryker |
| Rosario Dawson | Claire Temple |
| Alfre Woodard | Mariah Dillard |
| Sônia Braga | Soledad |
| Ron Cephas Jones | Bobby Fish |
| Karen Pittman | Inspector Priscilla Ridley |
| Michael Kostroff | Dr. Noah Burstein |
| Tijuana Ricks | Thembi Wallace |
| Deborah Ayorinde | Candace |
| Clifton Cutrary | Teenage Carl Lucas |
| Jared Kemp | Teenage Willis Stryker |
| Ninja N. Devoe | Aisha Axton |
| Jeremiah Craft | D.W. Griffith |
| Justin Swain | Detective Mark Bailey |
| John Clarence Stewart | Alex Wesley |
| Lee R. Sellars | Sergeant Jacob 'Jake' Smith |
| P.J. Marshall | ESU Lieutenant Mario Green |
| Andre Jackson | Marshall #1 |
| Ben Horner | Marshall #2 |
| Darius Kaleb | Lonnie Wilson |
| Jade Wu | Connie Lin |
| Clem Cheung | Jin Lin |
| Mike Britt | Eddie Axton |
| Anthony Aroya | Victor |
| Fab 5 Freddy | Fab Five Freddy |
| Robyn Payne | Female Reporter |
| Tristan Laurence | Male Reporter |
| Robert Siverls | Man |
| Corri English | Alicia |
| Joshua Rivera | Cameraman |
| The Dap-Kings | Sharon Jones & The Dap-Kings |
| Sharon Jones | Sharon Jones |
| Mahershala Ali | Cornell 'Cottonmouth' Stokes |
| Roger Brenner | FDNY |
| Ryan Burton | Fight Watcher |
| Merritt Chase | Harlem Precinct Detective |
| Lynn Marocola | NYPD Police Officer |
| Monet Marquis | Club Patron |
| Leroy Phillips Jr. | Onlooker |
| Derrick Williams | Boxing Trainer |